tirzepatide leg aches and Joint Inflammation: What the Evidence Shows Can Mounjaro (tirzepatide) cause muscle

July 7, 2026

Volatile agents and opioids can both depress sympathetic tone

However, stopping "cold turkey" can lead to sudden blood sugar spikes or rapid weight regain

In the SUSTAIN 6 CV outcomes trial (CVOT), once-weekly semaglutide (0.5 or 1.0 mg) added to standard of care significantly reduced the occurrence of a first major adverse CV event (MACE: CV death, nonfatal myocardial infarction [MI], or nonfatal stroke) vs placebo over 2 years in 3297 subjects with T2D and high CV risk [12]

The BNF advises caution and dose adjustment when these medicines are used together, and your GP will need to assess whether this combination is appropriate for you

externally peer reviewed.