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Metabolomic study of lipids in serum for biomarker discovery in Alzheimers disease using direct infusion mass spectrometry

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In the present study, the significant reductions of liver and plasma GSH (Table 3) and cystathionine concentrations (Table 2), in addition to the significant correlation between these two compounds, suggested that modulation of the methyl balance and the consequent reduction of Hcy can down-regulate the trans-sulfuration pathway in a dose-dependent response