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This may impair germ cell development and sperm function, induce Sertoli cell dysfunction, compromise the integrity of the bloodtestis barrier, promote immune-related injury, and ultimately contributing to male infertility (Hu et al., 2023
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However, many factors can disrupt tight junction integrity, leading to increased gut permeability, often referred to as leaky gut. This increased permeability allows larger molecules, bacterial products, and toxins to cross the gut barrier and enter the bloodstream, triggering immune responses and systemic swelling
In a randomized controlled trial, leukemia patients undergoing bone marrow transplant, preceded by high-dose chemotherapy, were given 100 mg/kg N-acetyl cysteine (NAC) or placebo daily for 15 days after the procedure
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