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J Ilam Univ Med Sci

Molecular pathology associated with altered synaptic transcriptome in the dorsolateral prefrontal cortex of depressed subjects

We employed an integrated cross-species framework that combined longitudinal preclinical studies in an established mouse model of TB meningitis utilizing clinical endpoints [mortality, neurological deficits, dynamic contrast-enhanced magnetic resonance imaging (MRI)] with parallel mechanistic studies in a newly developed 3D immune-vascularized human brain organoid model of TB meningitis and peripheral blood mononuclear cells (PBMCs) from patients with TB meningitis

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