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Irrespective of the challenges such as adverse effects associated with weight management medicines such as nausea and diarrhea and lack of combination therapy, the global obesity drugs market has high potential to grow at a significant rate and is expected to gain further momentum in the coming years due to a strong emphasis on new product development, greater acceptance in developing countries, positive impact of social media campaigns, and decreasing pricing trend due to competition, among others
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They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)
Cell 163 , 13601374 (2015)
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Clinical trials indicate that the weight loss results from oral semaglutide are similar to those of its injectable counterpart
