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Clinical Relevance: Explains why combination therapy produces synergistic rather than merely additive weight loss
DIO mice were randomized to treatment according to body weight (n = 15 per group) and dosed subcutaneously (5 ml/kg) for a total of 28 days with vehicle (QD), liraglutide (0.2 mg/kg, BID) or GUB09-145 (0.04 mg/kg, BID)
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& Scorrano, L
It should have been no mystery, then, that when the people of Hollywood started dropping dozens of pounds in a matter of weeks, it wasnt that everyone had suddenly started practicing moderation and logging 10,000 steps
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