However, after a large dose of APAP, the sulfonation reaction becomes saturated and the build-up of NAPQI depletes GSH in the liver, causing further accumulation of NAPQI
In adults, glutathione levels begin to decline noticably as early as age 30, and continue to decline more and more as we age
In the diagram below youll find the most common causes of glutathione depletion: Glutathiones Antioxidant Capabilities Glutathione is one of the most famous natural antioxidants known to mankind
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