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Level of Evidence Summary: Diabetic Peripheral Neuropathy: Moderate ([1][6]) Peripheral Neuropathic Pain (General): Moderate[11] Fibromyalgia: Low to Moderate[7][8][9] Central Sensitization/Nociplastic Pain: Low to Moderate (Strong mechanistic rationale

Its initiation is driven by iron overload, oxidative stress, inflammatory cytokines, and disrupted genetic pathways

GLP-1 medications are FDA-approved for certain medical conditions, and providers may also prescribe some of them off-label based on clinical judgment

Medical history: Relevant history related to metabolic health, insulin resistance, or other conditions that might make GLP-1 therapy appropriate

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For example, EVs secreted by cerulein-stimulated acinar cells delivered miR-183-5p, which downregulated forkhead box protein O1, promoted M1 macrophage polarization, and increased macrophage infiltration into the pancreas, ultimately leading to acinar cell injury and trypsinogen activation