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Our clinic offers advanced DNA testing services to analyze polymorphisms in genes such as GJB2 , KCNQ4 , GRM7 , SLC17A8 , and ATP2B2 , which are critical to cochlear hair cell function, auditory nerve integrity, and synaptic signaling

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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Kopan and Ilagan, 2009)