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Healthcare providers emphasize measurable progress rather than immediate transformation, highlighting improvements in appetite regulation, portion control, and metabolic response over several weeks

Unfortunately, only 56% of people with T2D had optimal risk factor control [4, 5]

It activates the tyrosine kinase activity of IGF-1 receptor (IGF-1R), induces downstream MAPK/ERK and PI3K/Akt pathways, promotes the expression of cell cycle proteins (Cyclin D1, E), and accelerates the transition of cells from G1 phase to Sphase

Future decision-making frameworks based on phenotype stratification and Bayesian integration should prioritize identifying who requires long-term maintenance versus a short-term window, and how to minimize the reproductive costs of post-discontinuation rebound

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