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In humans, glutathione is found in all tissues, with the highest levels found in the liver, eyes, spleen, pancreas, and kidneys
10.1038/s41598-017-03740-7 Sci Rep
They concluded that the upregulated levels of 8-iso PGF 2 and decreased glutathione (oxidized GSSG and reduced GSH) levels indicated a link between increased oxidative stress arising from lipid peroxidation and the downregulation of certain key proteins in the myocardium (114)
Although the equilibrium constant of the reaction favors the formation of SAH, under normal metabolic conditions, low intracellular concentrations of homocysteine and adenosine, SAH formed by transmethylation reactions is hydrolyzed into homocysteine and adenosine (Fig