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Occasional nausea is common with GLP-1 RAs, but persistent vomiting (GLP-1 related or not) can deplete electrolytes significantly
[1] [5] According to NICE guidance, GLP-1 receptor agonists like Trulicity are typically considered when other diabetes treatments haven't achieved adequate blood sugar control, particularly when weight is a concern or insulin is unsuitable
If you experience severe gastrointestinal symptoms, contact your GP promptly, as temporary discontinuation of metformin may be advisable until you are adequately hydrated to reduce the risk of acute kidney injury
PubMed PMID 37952131 cardiovascular outcomes in adults with overweight or obesity
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Alberti KG, Johnston DG, Gill A, Barnes AJ, Orskov H
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