Jin, Z., Zhang, C., Shen, L
Novo Nordisk - Regulatory Approval (December 2025): FDA approved the first oral GLP-1 for weight loss-Novo Nordisk's once-daily semaglutide pill-which launched in January 2026 [3]
For sleep apnea, Zepbound is the only FDA-approved medication
For example, a reduction in estrogen can lead to additional abdominal fat and muscle loss

GLP-1 Offerings and Weight Loss Services Nurx offers one of the widest medication menus in this review series, spanning brand-name GLP-1 injectables, compounded GLP-1 injectables, compounded oral semaglutide, and non-GLP-1 oral weight management medications: Brand-Name GLP-1 Injectables (prescription via Nurx, pick-up at local pharmacy): Wegovy (semaglutide), Ozempic (semaglutide), Mounjaro (tirzepatide), Zepbound (tirzepatide), Victoza (liraglutide), Saxenda (liraglutide) Compounded GLP-1 Products (shipped to home): Custom GLP-1 Injection Formula: compounded semaglutide (5mg or 7.5mg) with glycine weekly injectable Nurx GLP-1 Pill: compounded oral semaglutide with vitamin B6 and B12 a needle-free oral format using SNAC to improve absorption Nurx 3-in-1 Pill: compounded oral weight management combination starting at $75/month Non-GLP-1 Oral Medications: Naltrexone, Bupropion, Topiramate, and Metformin, several treatments may be prescribed together for a comprehensive oral medication plan Cash price for oral medication treatment plans: $60$329/month, depending on medications

It is important to note that cross-trial comparisons have significant limitations