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Ipamorelin is a ghrelin receptor agonist (GHS-R1a) that stimulates GH secretion through a mechanistically separate pathway

Following tissue injury, it is naturally released from damaged cells and participates in biological processes associated with tissue repair

Binding activates Gq/11 protein signalling, generating IP3 and DAG second messengers that raise intracellular calcium, triggering exocytosis of stored GH granules and stimulating GH gene transcription

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