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Weight appeared to plateau around weeks 44 to 48 for most participants, suggesting the body reaches a new equilibrium point rather than continuing to lose indefinitely

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Chirindel A, Chaudhry M, Blakeley JO, Wahl R

IGF-1 LR3 is modified at two positions (N-terminal 13-amino-acid extension and Arg3 substitution) to substantially reduce IGFBP-3 binding, extending preclinical activity duration well beyond the roughly 10 to 12 minutes seen with unbound native IGF-1

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GLP-1 receptor agonists (GLP-1RAs) show clinical promise, and the prevailing hypothesis is that their benefits are primarily driven by weight loss and the downstream benefits of improved functional status