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Under such conditions, even structurally optimized drugs or more potent inhibition of single signaling pathways can have their effects diluted, misdirected or compartmentalized by the architecture and dynamics of the TME [11, 17]

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Notably, 4-HNE can cause cellular damage, and its production is a hallmark of ferroptosis 40

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Knowing the differences between the two can help you choose the best one for your research