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This objectively quantifies changes in visceral fat, subcutaneous fat, and lean mass, allowing researchers to evaluate whether the combination is producing the hypothesized benefits (preferential visceral fat loss with muscle preservation)

Whether the lean mass preservation observed with combination liraglutide-plus-exercise translates to higher-magnitude weight loss on more potent agents is a question the published RCT literature has not yet definitively answered

[7] The relevance of these animal findings to human patients remains uncertain and is the subject of ongoing pharmacovigilance