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In December 2025, Winfrey told People that she went off the medication for a year because she wanted to prove that she could "do without it," but ended up gaining 20 pounds
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Treatment with GLP-1MK-801 led to a decrease in plasma cholesterol levels compared with vehicle treatment and treatment with either GLP-1 or MK-801 (Fig
doi:10.3945/ajcn.116.145110 Witard et al
Some are short-term and mild, while others may be long-term and more serious
It mimics endogenous GLP-1 with 94% homology but with extended half-life (~165 hours) due to albumin binding via a C-18 fatty di-acid side chain
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