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Studies have reported additive benefits in glycemic control, body weight reduction, and blood pressure lowering without major unexpected safety signals [40,41,42,43]
Still, the difference is large enough to be meaningful, and a direct head-to-head comparison is underway (see below)
But that entire safety dataset is three small animal studies with no formal toxicology arm, no dose escalation, no repeat dosing, no long-term follow-up, and nothing in humans
The authors concluded that supplementation of HA to collagen did not improve various skin parameters, and therefore, the dermal benefits of the HA active ingredient could not be confirmed in this study [53]
Catchpole, A
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