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[8] Since UVA is a major component of sunlight , the implication is that we evolved to rely on ergothioneine as part of our first-line defense against arguably the most common source of oxidative stress in the ancestral environment: sunlight

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Samples were separated using a Kinetex 2.6 m XB-C18 100 , 100 2.1 mm LC Column (Phenomenex) with a constant flow rate of 250 l/min following a flow gradient starting at 70% Mobile Phase B (ACN + 0.5% Acetic acid, AA) then going up to 99% for 5 min before re-equilibration at 70% for 5 min

Glutathione's antioxidant properties help protect cells from oxidative stress, which can contribute to a healthier-looking, more radiant complexion

Smith RG, et al

This can help counteract age-related declines in these hormones and support metabolic health