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Moreover, a previous study revealed that G6PD significantly affects REDOX homeostasis by regulating glycolytic flux through the pentose phosphate pathway (PPP) (Garcia et al., 2021)

10.1155/2016/2897656 15 BagheriA.RadmanG.AriaN.RezaeiF.KhajenouriM.GhiabiS.et al (2022)

Potthoff, M

This ultimately leads to the depletion of cellular glutathione and allows the toxic metabolite to bind to hepatic proteins resulting in hepatocellular damage (Nelson, 1990)