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These limitations may partially explain the discrepancy between promising preclinical results and the limited success observed in clinical trials
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Magnetic resonance imaging (MRI) in September 2016 revealed bilateral degeneration of the forearm proximal tendons and degenerative changes of the neck muscles, with progression of these changes shown in the study of March 2018 (Figure 1)
The side effect profiles also differ , and some researchers switch between the two based on response and tolerance
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