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Toxic doses in research have been measured at 300-3,750 times higher than therapeutic ranges, providing substantial safety margins

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At the same concentration of 580 M, Cu(OAc) 2 induced a higher upregulation of IL-1 than CuCl 2 , while CuCl 2 induced a higher upregulation of IL-8, HSPA1A and FOSL1 than Cu(OAc) 2