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doi: 10.3945/ajcn.2009.28169 201
Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional ( Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis
Another interesting class of drugs includes myostatin inhibitors, whose role is to help preserve muscle mass, which in alone or in combination with weight loss medications could help improve overall body composition, metabolism and health
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IP may move toward intracellular calcium stores and trigger calcium release into the cytosol, while DAG remains in the membrane and potentially activates PKC (protein kinase C)
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