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GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity

TRPM8 is expressed on trigeminal sensory neurons involved in migraine pain signaling and represents a biological pathway distinct from those targeted by existing migraine therapies, including calcitonin gene-related peptide (CGRP) receptor antagonists

Victoria Garfinkle

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Tirzepatide , a dual GLP-1/GIP receptor agonist, has been approved by NICE for type 2 diabetes management