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These complementary pathways create synergy when combined

In MASLD, circulating FGF21 levels correlate with inflammatory markers, and impaired FGF21 signalling is associated with exaggerated postprandial inflammation

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Although ACSL4 is consistently upregulated in OA cartilage and linked to ferroptosis progression, its inhibition must be balanced to avoid disrupting normal PUFA metabolism required for membrane integrity and repair (74, 77)