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Most people notice a change in appetite and weight within a few weeks to a few months

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J Neurosci 30(15):54375450 Ferrini F, De Koninck Y (2013) Microglia control neuronal network excitability via BDNF signalling

It is what the medication removes from your system

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If approved, treatment with Retatrutide may be suitable for: Adults who are Overweight: BMI 27 with related health conditions such as fatty liver disease, type 2 diabetes, sleep apnea, high blood pressure, or high cholesterol