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Liver tissues, hepatocytes, and Kupffer cells (KCs) were collected and analyzed by histology, RNAseq, secretome profiling, and cytokine array

In addition, acetaldehyde is highly reactive and capable of adducting proteins and lipids that, in turn, initiate a series of deleterious cellular events

M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C

5c and Extended Data Fig

Homocysteine Vitamin B12 deficiency leads to the accumulation of the amino acid homocysteine in the blood

This is of great importance since SOD3 is the major enzymatic antioxidant defense against vascular and cardiovascular diseases (neurological diseases, lung disease, atherosclerosis, diabetes, hypertension, inflammatory conditions and ischemia-reperfusion injury