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DSIP significantly increased the rate of phosphorylated respiration (V3), which represents the maximal oxygen consumption rate in the presence of ADP

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These findings are supported by (i) the decreased GPx1 mRNA in intestinal macrophages, and (ii) the decreased GPx1 protein observed in biopsies from inflamed gut regions from individuals with CD, although the immunohistochemistry did not co-stain for macrophage markers