Deficiency of vitamin B12 has been loosely associated with dementia and impaired cognitive functioning in elderly patients
Another reasonable trigger point is when you reach a body fat percentage where the remaining fat is concentrated in specific areas rather than distributed evenly
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doi: 10.1371/journal.pone.0271058 11
Cycling Approach: Some practitioners implement protocols such as 12 weeks on, 4-8 weeks off to theoretically prevent receptor desensitization, reduce long-term costs, or provide physiological breaks