As body weight decreases, metabolism adapts and calorie needs change
As cardiologists, we believe SOUL trial benefits are very likely to apply to Indian patients, especially since Indians often develop diabetes, obesity, and heart disease at younger ages and lower BMI levels.Studies and the STEP-HFpEF trials suggest symptom and functional improvement with semaglutide in obesity-related heart failure
By this stage of life, the cumulative decline in glutathione production is more significant
Research protocols typically employ intermittent dosing strategies (once weekly or 3-day cycles) designed to prevent excessive apoptosis while enabling effective senescent cell elimination, with doses ranging from 5-10 mg/kg body weight in animal studies
Always consult with a healthcare professional if youre unsure about supplementation
Continuous variables were reported as medians with interquartile ranges (IQR), and categorical variables as proportions