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Brain cancer, one of the rarest cancers, ranks 19th in terms of incidence, with 321,476 new cases and 12th in terms of mortality, with 248,305 deaths worldwide, according to GLOBOCAN 2022 [37]

Dosing Protocol Suggested approach for the 10 mg vial format

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Rondanelli M, Infantino V, Riva A, Petrangolini G, Faliva M, Peroni G, Naso M, Nichetti M, Spadaccini D, Gasparri C

Dihexoacylceramide (CerG2) 39:6, sterol (ST) 44:4 and phosphatidic acid (PA) 32:4 were upregulated, while cholesterol ester (ChE) 18:0, sphingomyelin (SM) 47:3, triacylglycerol (TG) 18:1/17:1/20:4, ceramide (Cer) 18:1/26:0 and SM 34:2 were downregulated (Figure 1)

3-Isobutyl-1-methylxanthine (IBMX), poly(D-lysine), and forskolin were from Sigma-Aldrich