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What Research Studies Have Compared These Two Medications Directly The primary direct comparison is SURMOUNT-5, a randomised controlled trial published in the New England Journal of Medicine (2025), which compared tirzepatide 10mg or 15mg against semaglutide 2.4mg in adults with obesity without diabetes over 72 weeks [10]
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Not a medicine, not evaluated by BPOM, and not for human or veterinary consumption
This is particularly beneficial for those struggling with obesity, as it addresses both physiological and psychological aspects of eating
Retatrutide is a triple agonist of the GIP, GLP-1, and glucagon receptors that is currently in development
This article delves into the role of GLP-1 agonists in medical weight loss, their safety, efficacy, and cost considerations, as well as comparisons with other weight loss options
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