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PMID: 18347346 Hermansen K, et al
Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity
hype, and what truly supports metabolic health - no gimmicks required
MedicalDaily Evidence Check Study type: Phase 3 randomized controlled trial (ATTAIN program) Participants: Adults with obesity or overweight with at least one weight-related comorbidity Approval date: April 1, 2026 What it found: Average weight loss of approximately 12.4% (about 27 lbs) at highest dose over 72 weeks What it did not prove: That it matches injectable GLP-1 efficacy
Huo et al., 2020
Neurons that produce dopaminea chemical with pivotal involvement in motivation and pleasureproject to the nucleus accumbens, a midbrain structure important for experiencing reward, explains Patricia Sue Grigson, a neuroscientist and addiction researcher at Penn State College of Medicine
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