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Annesley, T
In particular the Asp 73 -Lys 76 loop of Fab 3F52 overlaps with Thr 13 only 6 residues away from the N-terminal histidine (His 7 ) of GLP-1 which is critical for receptor activation
The crystal structures of un-acylated liraglutide and semaglutide are almost identical to GLP-1 (737)
Why liposomal
For instance, semaglutide for diabetes (Ozempic) typically starts at 0.25 mg weekly, increasing monthly until reaching the maintenance dose of 1 mg or 2 mg weekly
Retrieved from Papatriantafyllou, E., Efthymiou, D., Zoumbaneas, E., et al
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