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This imbalance is believed to be manifested in most brain regions, including the amygdala, cortex, and hippocampus, and plays a central role in several pathological conditions, such as Fragile X Syndrome (FXS), epilepsy, and ASD

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British Journal of Biomedical Science, 70, 759

29,32 The neutral and basic amino acid transporter (RBAT, also designated by SLC3A1 ) is another cystine transporter with possible implications in cancer development

Additionally, metabolites such as lactate bidirectionally regulate macrophage polarization stability through epigenetic modifications like H3K18 lactylation, yet their dominant effects and functional thresholds within specific microenvironments remain largely unknown

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