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Over-the-Counter & "Natural" Alternatives: Evaluating the Claims The massive popularity of GLP-1 medications has spawned a parallel market of over-the-counter (OTC) supplements and natural remedies marketed as "natural alternatives" or "Nature's Ozempic." It is clinically important to distinguish between social media marketing and scientific evidence

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In the brain, the GHSR 1a is expressed most highly in agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons of the hypothalamus