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doi:10.1289/ehp.119-a80b

A series of edaravone derivatives bearing N -benzyl pyridinium moieties demonstrated significant in vitro acetylcholine inhibitory activity (with low activity toward butyrylcholinesterase) and antioxidant effect (Zondagh et al., 2020)

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this number increased to over $69 billion in 2009 (Simoens 2007