[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis
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For comparison of outcomes between men and women, estimated hazard ratios (HRs) and associated confidence intervals (CIs) were determined by a Cox proportional hazards model with an interaction between treatment (semaglutide, placebo) and gender as a fixed factor
PMC 4995287
Transdermal delivery provides gradual, steady release through the skin over several hours