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Comprehensive genomic profiling using a hybrid capture-based DNA+RNA sequencing platform (Caris Life Sciences) revealed a PRKAR1A p.S321fs* pathogenic frameshift mutation (RefSeq transcript NM_001276289.1

GLP-1 and GIP receptors downregulate slightly in response to sustained agonist exposure

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This results in an overall decrease in blood sugar levels, which then triggers adipose tissue as well as the liver to begin breaking down glycogen and triglycerides

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