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In the renal cortex of patients with chronic kidney disease (CKD), GSH expression is reduced, whereas oxidative stress and ROS levels are elevated [203]

268 AXL activation mediates both intrinsic and acquired resistance to targeted therapies (e.g., EGFR-TKIs in NSCLC, HER2 inhibitors in breast cancer), chemotherapy (e.g., cisplatin, gemcitabine), and antiangiogenic agents (e.g., bevacizumab)