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Per-Compound Adverse Events Retatrutide The Jastreboff 2023 Phase 2 trial (Jastreboff et al., 2023) and the TRIUMPH-4 Phase 3 trial (Bays et al., 2025) anchor retatrutide's safety profile
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Study participants were clinically overweight and had cardiovascular disease, and were randomly assigned to receive weekly injections of semaglutide or a placebo
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