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The slow titration can help with the tolerability as nausea is a common class adverse effect

Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimers disease dementia

But while we have decades of monitoring data on rhGH, we have almost nothing for peptides in children

For patients with more troublesome side effects, additional strategies are often necessary to manage symptoms and permit drug continuation

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

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