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10.1126/science.1219855 54 ZhangH.DuanC.YangH
These are significant indicators of success
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Semaglutide works by activating GLP-1 receptors in the body, which causes increased insulin production, reduced glucagon secretion, and appetite suppression
Some participants reported initial challenges adapting to dramatically reduced appetite, requiring counseling to ensure adequate nutritional intake
In the trial mentioned above, one year after stopping the GLP-1 medication, participants also saw: Blood pressure levels go back up C-reactive protein levels (an indicator of inflammation) increase VLDL cholesterol (a type that leads to hardened arteries) goes up Triglycerides (a type of blood fat) go up Hemoglobin A1c increases (meaning the level of sugar in the blood) At high levels, these health markers are associated with conditions like type 2 diabetes, obesity, hypertension, and heart disease, to list a few
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