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Role in bioactivation and detoxication mechanisms of xenobiotics
Milk Thistle Side Effects And Safety Common Side Effects Milk thistle appears to be well-tolerated but can cause mild digestive symptoms, such as: Bloating, fullness, gas, or stomach pain Heartburn Nausea Changes in bowel habits Diarrhea Rare Side Effects Stop taking milk thistle and seek emergency medical care if you develop signs and symptoms of allergic reactions: Skin reactions (rash, hives, itching, eczema) Severe allergic reaction (anaphylaxis), including throat tightening, swelling, and difficulty breathing Warning: The risk of an allergic reaction to milk thistle is higher in people who are allergic to related plants such as ragweed, marigold, daisy, and chrysanthemum
Cardiovascular considerations Oral estrogen slightly increases the risk of venous thromboembolism (blood clots)
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