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10.23937/2572-4061.1510021 2 AlakG.UarA.ParlakV.AtamanalpM

The two major transcription factors: i) the NFB upregulates the pro-oxidant mediators, and ii) the Nrf2 activates the antioxidant responses 622

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Taken together, these findings indicate that imatinib-induced reproductive toxicity is highly context-dependent, shaped by the interplay of dose, developmental timing, and individual susceptibility, and should therefore be interpreted with caution when translating experimental evidence into clinical practice