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Importantly, the Nrf2 signaling pathway has been linked to safeguarding against myocardial injury induced by ischemia/reperfusion (I/R), protecting against oxidative stress, and addressing electrolytes imbalances 45

This supports a model in which CHAC1-mediated GSH depletion destabilizes NRF2 and reduces cystine import, allowing iron-dependent lipid peroxides to accumulate and trigger ferroptosis

It could even help reduce symptoms of certain skin conditions, as well

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