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This is not typical for IV use, but anyone with asthma should mention it to the provider beforehand

The maintenance dose varies based on the condition being treated

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Research has not demonstrated significant differences in efficacy between morning and evening administration for once-daily or once-weekly formulations, provided the medication is taken regularly

However, favoring the theory of hyperhomocysteinemia-induced platelet activation, in vitro studies have proposed that, besides its direct cytotoxicity that damages endothelial cells (Dudman et al, 1991

In SURMOUNT-1, the incidence was less than 0.2 percent