This wasn't an isolated success
Studies with human participants and studies involving actual human tissue samples where liver injury or hepatotoxicity is detailed, including mechanistic studies, case series, observational studies and randomised controlled trials, reviews, and systematic review articles Exclusion criteria 1
EMEA, Committee for Medicinal Products for Human Use (CHMP)
Numerous drugs, including glucose-lowering medications, are undergoing assessment for NAFLD/NASH treatment
However, given the neutral effect of GLP-1 RAs on surrogate HF outcomes in HFrEF and a potentially increased risk of arrhythmias and HF-related hospitalisations, conducting further large-scale trials in the HFrEF cohort seems complicated
Finally, we observed no effects of ALCAR in inducing cell cycle arrest, both in the PCa and BPH cell lines (Additional file 1: Figure S2 a-d)