When dramatic clinical claims persist for decades without the backing of even small randomized controlled trials, the most plausible explanation is not a lack of economic incentive, but rather a profound scientific weakness or an unattractive risk-benefit profile
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Also, it was shown that the epigenetic changes (DNA methylation patterns) to be associated with oxidative stress markers 39,40
This black box warning is critical to ensure patient safety, particularly in avoiding life-threatening serotonin syndrome in vulnerable populations
